Web4 Apr 2016 · It is comparable in action to an artificially introduced miRNA sponge but distinguished by its endogenous origin. ceRNA network A collective pool of transcripts … Web23 Oct 2012 · STTM is a powerful technology complementing the previous target mimic (TM) in plants and the miRNA sponge, as well as the recently defined endogenous competing RNA (CeRNA) in animals. We expect STTM will not only be effective in blocking small RNA functions in plants but will also become a popular approach in animals.

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WebThe miRNA Sponge, ceRNA Hypothesis, and its Generalization. miRNAs are a class of small [approximately 22 nucleotides (nt)], regulatory ncRNAs that are incorporated into the RNA-induced silencing complex and bind to their target mRNAs to modulate target gene expression [8. Bartel D.P. Web4 Sep 2024 · SpongeScan uses a sequence-based algorithm to detect potential sponge interactions [ 21 ]. The algorithm is applicable whenever sequence data is available but does not account for the expression of the RNAs, which provides evidence on the interaction of the RNA species within a given context. karndean art select hickory peppercorn

Long noncoding RNA TRPM2-AS acts as a microRNA sponge of …

Web21 Aug 2024 · The most researched mechanism of miRNA–lncRNA interplay, the ceRNA activity, has been delineated in several physiological states and complex diseases, such as cancer. An interesting example is the “sponge ” activity of X-inactive specific transcript (XIST) on bound miRNAs that either suppresses or promotes tumor cell proliferation [ 27 , … Web目前研究表明ceRNA与肿瘤密切相关，并影响肿瘤的发生；Salmena等[1]提出的ceRNA假说是研究转录后调控机制的热门方向。现阶段ceRNA的发病机制尚未完全阐述清楚，但有研究发现ceRNA在消化系统肿瘤中发挥重要作用，为ceRNA在肿瘤发生、发展中的机制提供新的诊 … WebLinc-ROR was first identified in pluripotent stem cells as a ceRNA of miRNAs involved in core transcription factors regulatory circuitry . ... to show that linc-ROR promotes the survival of breast cancer cells during rapamycin treatment by functioning as a ceRNA sponge for miR-194-3p, which targets the methyl-CpG binding protein 2 (MECP2). karndean art select rl01