WebApr 1, 2009 · Phospholemman and the Na/K ATPase in the diseased heart Not only is the activity of the Na/K ATPase crucial for the maintenance of the normal trans-membrane Na gradient in the healthy heart, but there is increasing evidence that perturbation of this gradient may also play a crucial role in the pathophysiology of ischaemia/reperfusion [19•, … WebPhospholemman (PLM) or FXYD1 is a major cardiac myocyte phosphorylation target upon adrenergic stimulation. Prior immunoprecipitation and functional studies suggest that …
Phospholemman Phosphorylation Regulates Vascular Tone, Blood Pre…
WebOct 25, 2015 · FXYD1 (phospholemman) is a member of an evolutionarily conserved family of membrane proteins that regulate the function of the Na,K-ATPase enzyme complex in … WebAug 18, 2010 · Phospholemman (PLM), a member of the FXYD family of regulators of ion transport, is a major sarcolemmal substrate for protein kinases A and C in cardiac and skeletal muscle. In the heart, PLM co-localizes and co-immunoprecipitates with Na + -K + -ATPase, Na + /Ca 2+ exchanger, and L-type Ca 2+ channel. nottingham biocity investment
Identification of a Cytoskeleton-bound Form of Phospholemman …
WebPhospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during β-adrenergic stimulation in mouse ventricular myocytes — University of Kentucky Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during β-adrenergic stimulation in mouse ventricular myocytes Web13721-1-AP targets Phospholemman/FXYD1 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. WebSep 1, 2009 · Cardiac Na+-K+-ATPase (NKA) regulates intracellular Na+, which in turn affects intracellular Ca2+ and contractility via the Na+/Ca2+ exchanger. Extracellular K+ concentration ([K+]) is a central regulator of NKA activity. Phospholemman (PLM) has recently been recognized as a critical regulator of NKA in the heart. PLM reduces the … how to shoot in hoop life roblox