WebDrug Interaction Studies . Effect of Omeprazole on Other Drugs Omeprazole is a time-dependent inhibitor of CYP2C19 and can increase the systemic exposure of co-administered drugs that are CYP2C19 substrates. ... Concomitant administration of omeprazole 20 mg once daily and diazepam 0.1 mg/kg given intravenously resulted in 27% decrease in ... Web17. avg 2024. · 4. Bottom Line. Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed areas of …
Effect of omeprazole treatment on diazepam plasma levels in …
Web28. dec 2024. · The extent of the inhibitory effect of omeprazole on diazepam metabolism is dependent on ethnicity. The decrease in diazepam clearance and the prolongation in t 1/2 of diazepam and desmethyldiazepam after pretreatment of omeprazole 40 mg once daily for 21 days were significantly greater in the Caucasian group than in the Chinese group. … WebThere are 4 other medicines that are similar to omeprazole. They are: lansoprazole; esomeprazole; pantoprazole; rabeprazole; Like omeprazole, these medicines are proton … the turbine hall
Full article: Pharmacokinetic drug interaction profile of omeprazole ...
WebEsomeprazole does not seem to have any potential to interact with drugs that are metabolised by cytochrome P450 (CYP) 1 A2, 2A6, 2C9, 2D6 or 2E1. In drug interaction studies with diazepam, phenytoin and (R)-warfarin, it was shown that esomeprazole has the potential to interact with CYP2C19. The slightly altered metabolism of cisapride was also ... WebThe effect of omeprazole treatment on diazepam plasma levels was studied in four slow and six rapid metabolizers of omeprazole. Single intravenous doses of diazepam (0.1 mg/kg) were administered after 1 week of oral treatment with omeprazole (20 mg) and placebo. This was a double-blind crossover stu … WebEletriptan. Both Sertraline and Eletriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome' and 'Monoamine-oxidase inhibitor' under Antidepressant drugs in BNF for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. sewing table fold down top