Hsulf-2

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August undefined, 2024

Web28 okt. 2010 · Lai et al. (2003) cloned 2 splice variants of SULF1 that differed from one another and from the sequence reported by Morimoto-Tomita et al. (2002) ... Sasisekharan, R., Sanderson, R. D. HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J. Biol. Chem. 280: 40066-40073, 2005. Web14 mrt. 2011 · Recently, endosulfatases 1 and 2 (HSulf-1 and -2) were identified which function to remove sulfate moieties at 6-O positions of glucosamine . Recent report suggests that HSulf-1 and -2 knockout could lead to upregulation of HS biosynthetic enzymes culminating in differences in 2-O and N-O sulfation in mouse embryonic fibroblasts …

Anti-Sulf-2 Antibody, clone 8G1 - Sigma-Aldrich

Web1 feb. 2010 · HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1. K. … WebOur results enabled us to propose a new model depicting the desulfation process of HS by the Sulfs. Second, we have shown that HSulf-2 is a proteoglycan, given that it harbors a unique PTM... hawaiian airlines to alaska

Anti-Sulf-2 Antibody, clone 8G1 - Sigma-Aldrich

Web20 feb. 2024 · 2: Amino acid sequence of HSulf-2. Within the sequence, the HD domain (R416-Q715) is shown in italic and grey, catalytic cysteine modified FGly (C88) is shown in red and R 538 S furin cleavage site … Web3 apr. 2024 · In human, HSulf-1 and HSulf-2 (encoded by two distinct genes) feature a common structural organization . Maturation of the sulfs involves furin-type processing of pro-enzyme proteins, yielding two sub-units linked by … WebHuman sulfatase‑1 (HSulf‑1) is emerging as a novel prognostic biomarker in breast cancer. Previous studies demonstrated HSulf‑1 to function as a negative regulator of cyclin D1 in … raine viitas

Extracellular endosulfatase Sulf-2 harbors a chondroitin ... - PubMed

RESEARCH Open Access Loss of HSulf-1 promotes altered lipid metabolism ...

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954. • Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequence… Web1 mrt. 2013 · Here, we have combined an array of analytical approaches, including mass spectrometry, NMR, HS oligosaccharide sequencing, and FACS, to dissect HSulf-2 … hawaiian homes kapoleiWeb3 apr. 2014 · Relative mRNA expression of HSulf-2 was measured by real-time RT-PCR. (B) Differentiated Caco-2 cells were stimulated by 0.1 mg/mL pectin with or without RGD peptide for 1 h. After the medium was exchanged, cells were incubated for 6 h. Relative mRNA expression of HSulf-2 was measured by real time RT-PCR. rainey joseph hayne

"WebhSulf-2. Gene names. Name. SULF2. Synonyms. KIAA1247. ORF names. UNQ559/PRO1120. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. ... This entry describes 2 isoforms produced by Alternative splicing. Q8IWU5-1. This isoform has been chosen as the canonical sequence. " - Hsulf-2

Hsulf-2

Web目的:研究新型紫杉烷类衍生物Lx2-32c体内外对人卵巢癌A2780细胞的生长抑制作用并探讨其机制.方法:体外实验采用培养的人卵巢癌A2780细胞株,利用集落形成法测定Lx2-32c对A2780细胞克隆原细胞的影响,流式细胞术(FCM)测定细胞周期的变化,间接免疫荧光方法观察细胞内微管动力学的改变.体内实验采用人癌 ... Web8 feb. 2024 · In conclusion, our results highlight HSulf-2 as a unique proteoglycan enzyme and its newly-identified GAG chain as a critical non-catalytic modulator of the enzyme activity. These findings contribute in clarifying the conflicting data on the activities of the Sulfs and introduce a new paradigm into the study of these enzymes.

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WebAnti-Sulf-2 Antibody, clone 8G1 clone 8G1, from mouse; Synonyms: Extracellular sulfatase Sulf-2, hSulf-2; find Sigma-Aldrich-MABC586 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Web1 sep. 2008 · Sensitive and selective detection necessitates the design of high affinity fluorescent probes for the extracellular sulfatases HSulf-1 and HSulf-2. This proposal describes the design of fluorophores which should undergo significant alterations in quantum yield or emission after hydrolysis by extracellular sulfatases.

Web4 jan. 2024 · Here we show that human Sulf-2 (HSulf-2) features a unique polysaccharide post-translational modification. We identified a chondroitin/dermatan sulfate … WebHuman Gene SULF2 (ENST00000359930.8) from GENCODE V38 Description:Homo sapiens sulfatase 2 (SULF2), transcript variant 1, mRNA. (from RefSeq NM_018837) RefSeq Summary (NM_001161841):Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved …

WebThis review presents the recently postulated role of FAS in: a) synthesis of natural ligands of PPARalpha; b) feeding behavior; c) endothelial NO production; d) protection of cardiomiocytes from pathological calcium influx; and e) diet induced atherosclerosis. Fatty acid synthase (FAS)--enzyme present in many tissues, catalyses synthesis of palmitate … Web15 mrt. 2024 · El Masri et al. show that human extracellular endosulfatase HSulf-2 harbors a glycosaminoglycan (GAG) chain that modulates its ability to bind and desulfate heparan sulfate and tunes its tumor-promoting properties in vivo. Removal of HSulf-2 GAG chain can be achieved by mammalian hyaluronidases, another class of GAG-processing enzymes.

Web1 jul. 2024 · HSulfs are biosynthesized as single polypeptide chain pro-enzymes (871 and 870 amino-acids for HSulf-1 (Q8IWU6) and HSulf-2 (Q8IWU5), respectively) comprising …

Web14 dec. 2024 · Here, we used CHO-HSulf-2 cells whose HS S-domains were reduced by stable expression of HSulf-2 to evaluate whether uptake of p53 aggregates depends on HS S-domains. Amount of recombinant p53 in cell lysates of CHO-HSulf-2 was significantly smaller than that of CHO WT cells (60%), which suggests that CHO-HSulf-2 cells took … hawaiian bbq mission viejoWeb29 mrt. 2024 · The activity of sulfatase 2, a major form of endosulfatase in hepatocellular carcinoma can be studied, in connection with the interactions between heparan sulfate … raine simonWeb27 aug. 2024 · FAST paced instructions/tips on how to replace the AC compressor on this 2010 Nissan Rogue 2.5L. Thanks for watching and consider checking out my main chann... hawaiian christmas jokesWeb1 mrt. 2013 · HSulf-2 targets both NRE and internal S-domains of cell-surface HS. Since we showed that HSulf-2 initiated desulfation of isolated S-domain-like H8 from its NRE, we next investigated how the enzyme would process intact HS chains at the cell surface. hawaiian home lands on molokai mapWeb3 feb. 2014 · Figure 2. Effects of hSulf-1 on stat3 signaling in HepG2 cells. (A and B) Expression of the indicated factors was examined by western blotting. (C and D) The phosphorylation of stat3 and expression of total stat3 protein were analyzed by western blotting followed by densitometry in hSulf-1 and empty vector transfected cells. hawaiian electric kailua konaWeb21 mrt. 2024 · Entrez Gene Summary for SULF2 Gene. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines … rainer wölk musikWeb20 aug. 2012 · HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD. J Biol Chem, (48):40066-40073 2005 MED: 16192265 hawaiian environment