Ctbp ogdhl

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August undefined, 2024

WebJul 31, 2024 · ogdhl沉默后，以αkg依赖性方式激活了mtorc1信号通路，从而诱导了在新生脂肪形成中具有关键作用的酶发生转录，进一步说明了ogdhl的功能。前面的功能实验 …

Silencing of OGDHL promotes liver cancer metastasis by …

The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to function as transcriptional corepressors. That is, regulatory proteins that bind to sequence-specific DNA-binding proteins and help turn genes off. CtBPs do this by recruiting histone modifying enzymes that add repressive histone marks and remove activating marks. CtBP proteins can also self-as… WebOgdhl: Name: oxoglutarate dehydrogenase L: RGD ID: 1310916: Description: Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. bithynia flag

NM_018245.3(OGDHL):c.2333C>T (p.Ser778Leu) AND Yoon-Bellen ...

WebConclusion: Our findings established that silencing of OGDHL contributed to HCC development and survival by regulating glutamine metabolic pathways. OGDHL is a … WebMar 21, 2024 · OGDHL (Oxoglutarate Dehydrogenase L) is a Protein Coding gene. Diseases associated with OGDHL include Yoon-Bellen Neurodevelopmental Syndrome … WebOGDHL has 3,312 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 66 datasets. Click the + buttons to view associations for ... bithy meaning

OGDHL Is a Modifier of AKT-Dependent Signaling and NF- B …

Entry - *617513 - OXOGLUTARATE DEHYDROGENASE-LIKE …

WebNov 13, 2007 · The OGDHC complex comprises multiple copies of three catalytic enzyme components, the 2-oxoglutarate dehydrogenase (OGDH/E1), the dihydrolipoamide … WebJul 22, 2024 · Hepatocyte-specific SIRT5 overexpressing mice (liver SIRT5 OE) were generated to address the possible involvement of hepatic SIRT5 in AMI. The areas of myocardial infarction, myocardial fibrosis, and cardiac function in a model of experimental myocardial infarction were compared between liver SIRT5 OE mice and wild-type (WT) … data analytics certification courses onlineWebPaperwork Reduction Act Notice: An agency may not conduct or sponsor an information collection and a person is not required to respond to this information request unless it … bithynia bible

"WebThe overexpression of OGDHL also markedly suppressed the growth of HCC-LM3/OGDHL xenograft tumors in immunodeficient mice (p = 0.014; Figure 8C,D); these findings were … " - Ctbp ogdhl

Ctbp ogdhl

WebApr 9, 2024 · CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; NM_001377187.1 → NP_001364116.1 C-terminal-binding protein 1 isoform 4. Status: REVIEWED. Source sequence(s) AC092535 Consensus CDS CCDS93461.1 UniProtKB/TrEMBL H0Y8U5 Conserved Domains (1) summary … WebKnockdown of OGDHL expression in cervical cancer cells expressing endogenous OGDHL had the opposite effect. Forced expression of OGDHL increased the production of …

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WebThe pro-metastatic role of OGDHL downregulation is most likely attributed to its upregulation of HIF-1α transactivation activity and the protein stabilization by promoting the accumulation of L-2-HG to prevent the activity of HIF-1α prolyl hydroxylases, which subsequently causes an epithelial–mesenchymal transition process in HCC cells. WebFeb 25, 2024 · In a 15-year-old girl (BAB4852), born of consanguineous Turkish parents, with Yoon-Bellen neurodevelopmental syndrome (YOBELN; 619701), Yoon et al. (2024) identified a homozygous c.2333C-T transition (c.2333C-T, NM_018245) in exon 18 of the OGDHL gene, resulting in a ser778-to-leu (S778L) substitution at a conserved region in …

WebOGDHL activated the mTORC1 signaling pathway in an α-KG-dependent manner, which in turn transcriptionally induced expression of SCD1 and FASN, thus, enhancing de novo lipogenesis. Meanwhile ... WebTissue proteome. GENERAL INFORMATIONi. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. OGDHL.

WebMay 31, 2024 · Scientists found that osteopontin is a bad player. It also supports a “good actor” role for an enzyme called 2-Oxoglutarate Dehydrogenase-Like or OGDHL. In the presence of elevated levels of osteopontin, however, OGDHL becomes dysregulated. WebAug 5, 2024 · OGDHL oxoglutarate dehydrogenase L Gene ID: 55753, updated on 5-Aug-2024 Gene type: protein coding Also known as: YOBELN See all available tests in GTR for this gene Go to complete Gene record for OGDHL Go to Variation Viewer for OGDHL variants Summary

WebJan 25, 2024 · The ketoglutarate dehydrogenase complex (KGDHC) consists of three different subunits encoded by OGDH (or OGDHL), DLST, and DLD, combined in different stoichiometries. DLD subunit is shared between KGDHC and pyruvate dehydrogenase complex, branched-chain alpha-keto acid dehydrogenase complex, and the glycine …

WebOct 17, 2024 · Background and Objective . Liver cancer is a highly malignant tumor, and patients typically have poor prognoses. Metabolic reprogramming is a hallmark of cancer, and downregulation of … bithynia fuchsianaWebAug 14, 2015 · The OGDHL promoter methylation pattern was assumed to provide a marker for differential diagnosis of CIMP+ (CpG island methylator phenotype) tumors, which display dense hypermethylation of the promoter region in many genes. Cell metabolic reprogramming is one of the cancer hallmarks. Glycolysis activation, along with … bithynia leachiiWebImmunohistochemistry of paraffin-embedded human brain using 17110-1-AP (OGDHL antibody) at dilution of 1:100 (under 10x lens). Mouse kidney tissue were subjected to … data analytics certification jobsWebtogether, these data suggest genetic insult of DHTKD1 and OGDHL as predisposing factors in driving mito-chondrial dysfunction and molecular pathways linked to the progression of allergic inflammation. Results WES analysis of EoE. Analysis of WES data from the study cohort, including the filtering methods used to iden- ... data analytics certification harvardWebMay 1, 2024 · To further examine the functional impacts of OGDHL in hepatoma cell progression, we constructed shRNA-OGDHL-knockdown clones (sh-A and sh-B) in Bel … data analytics certification microsoftWebThe CTP Portal is intended for use by regulated tobacco Industry, including manufacturers, importers, and distributors who make submissions to CTP. The CTP Portal should … bithynia in the bibleWebOGDHL Is a Modifier of AKT-Dependent Signaling and NF-kB Function Tanusree Sen1, Nilkantha Sen2, Maartje G. Noordhuis1, Rajani Ravi1, T-C Wu3, Patrick K. Ha1,4, David Sidransky1, Mohammad Obaidul Hoque1* 1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United … bithynia definition